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IBC 2011, vol. 3, article no. 11, pp. 1-6 | doi: 10.4051/ibc.2011.3.3.0011
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Rapid Report (Medical informatics)
Body Height Effect on Brain Volumes in Youth Decreases in Old Age in Koreans
InSong Koh1,*
1
Kyung Hee University, Dept. of Biomedical Engineering and Hanyang University, Dept. of Physiology, Republic of Korea
*Corresponding author
received: August 12, 2011 ; accepted: August 12, 2011 ; published : August 22, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Synopsis

The MRI (magnetic resonance imaging) volumetric analysis of the brain was performed in 59 healthy elderly Koreans (aged 62-76 years; 34 male, 25 female) to investigate whether the previously reported significant correlations between body height and brain volumes in the young aged Koreans (20’s) still exist in the old aged Koreans (60’s and 70’s). Unlike previously reported significant correlations in the young aged Koreans, neither the correlation between whole brain volume and body height in male nor the correlation between cerebellar volume and body height in female show any significance in the old aged Koreans. The significant correlation between body height and whole brain volume was still observed when both male and female data were combined (r=0.27, P<0.05), but the correlation coefficient and the level of significance markedly decreased from those of previously reported Korean youth data (r=0.67, P<0.01). Simple linear regression analysis shows decrease of explanatory power of height (measured in r2) from 44% in the youth group to 7% in the old age group on the variance of whole brain volume. Multiple linear regression analysis shows that age and sex, rather than height, are major explanatory variables for whole brain volume in the old aged Koreans. The loss of correlations in the aged group is suspected to be mainly due to age related brain volume changes.

Keywords : body height, brain volume, Korean, magnetic resonance imaging, age, sex
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:: Comments
::C1::In this article, the author reports interesting findings on the relation between the body height and brain volume among the old-aged Koreans in their 60’s and 70’s (n = 59) by using the MRI volumetric method. This study was based on a previous report by Koh et al. showing the positive correlation between the height and brain volume in the young Korean population of their 20’s by the same volume measurement and analysis strategies (n = 60). Similar to the young subjects, the older subjects showed significant correlation of the whole brain and lateral ventricular volume with the body height, which was not the case in separated same sex groups. Even though follow-up studies with subjects of larger sample sizes are desired, this report certainly provides constructive and statistically analyzed information.
Posted by: BH-BLSA ( 2011-09-22 )
::C2::This article presented interesting finding on the correlation between body height and brain volume using MRI volumetric analysis of the brain. The significant correlation between body height and brain volume shown in young aged Koreans no longer exists in old aged Korean. By using multiple regression statistics, the author clearly showed that the effect of age on the reduction of brain volume abolished that correlation. Although the sample size is modest in this study, the major point of the article is nicely analyzed using appropriate statistics. It would strengthen the statistical result if the matching height samples between young and old groups were used at least. Also, more detailed introduction on methodology of previous studies would allow readers to compare multiple cross researches. Finally, it would be a more interesting article if the author could mention the implication of the correlation between body height and brain volume.
Posted by: BLSA- EK ( 2011-12-08 )
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