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Journal Article Synopsis
IBC 2011, vol. 3, article no. 6, pp. 1-4 | doi: 10.4051/ibc.2011.3.2.0006
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Rapid Report (Systems biology, Medical informatics)
DMBase: An Integrated Genetic Information Resource for Diabetes Mellitus
Sun Young Lee1, Young-Kyu Park1, Jaeheup Kim2 and Young Joo Kim1,*
1
Genomics Resource Center, KRIBB, 125 Gwahag-ro, Yusong-gu, Daejeon 305-806, Republic of Korea
2
Cogent Biotechnology Inc., Rockville, MD 20850, USA
*Corresponding author
received: March 31, 2011 ; accepted: April 05, 2011 ; published : April 06, 2011
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Synopsis

Diabetes Mellitus (DM), often simply referred to as diabetes, has developed into a major health concern affecting more than 200 million people worldwide with approximately 4 million deaths per year attributed to the presence of the disease. Diabetes mellitus is categorized as Type 1 and Type 2, where Type 1 diabetes represents a lack of insulin production, and Type 2 diabetes is characterized by a relative lack of insulin receptor (i.e., decreased sensitivity to the effect of insulin) and cased by a complex interplay between genetic factors and environmental factors. Up to date, various studies on the pathology and mechanism in terms of genetic experiments have been conducted and approximately hundreds of genes were reported as diabetes mellitus associated genes. At this point, to support studies on the cause and mechanism of diabetes mellitus, an efficient database system to provide genetic variants related to diabetes mellitus is needed. DMBase is an integrated web-based genetic information resource for diabetes mellitus designed to service genomic variants, genes, and secondary information derived for diabetes mellitus genetics researchers. The current version of DMBase documents 754 genes with 3056 genetic variants and 66 pathways. It provides many effective search interfaces for retrieving diabetes mellitus and genetic information. A web interface for the DMBase is freely available at http://sysbio.kribb.re.kr/dmBase.

Keywords : diabetes mellitus, genetics, web interface, obesity, systems biology
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:: Comments
::C1::This DMbase system looks very useful. I will look into it to see if there’s anything useful for my research as well. Very nicely organized.
Posted by: NE ( 2011-04-27 )
Declaration of Competing Interests :
Author
::C2::Thanks very much for your valuable comment. We will try to update the database as best as we can.
Posted by: DMbase ( 2011-04-29 )
::C3::The developed DMBase will be useful to provide genetic information associated with DM and obesity. Mechanism and pathogenesis of DM can be easily identified by this DB base.
Posted by: iyangbio@********** ( 2011-12-13 )
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Reviewed by
- Keun-Joon Park
- Leeyoung Park
Edited by
- Keun Woo Lee
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- Young Joo Kim
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